Scipediacontent: Scipediacontent moved page Draft Content 339978612 to Andersson et al 2019a

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Scipediacontent moved page Draft Content 339978612 to Andersson et al 2019a

Scipediacontent: Created page with " == Abstract == The infant brain is unlike the adult brain, with considerable differences in morphological, neurodynamic, and haemodynamic features. As the majority of curren..."

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Created page with " == Abstract == The infant brain is unlike the adult brain, with considerable differences in morphological, neurodynamic, and haemodynamic features. As the majority of curren..."

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== Abstract ==

The infant brain is unlike the adult brain, with considerable differences in morphological, neurodynamic, and haemodynamic features. As the majority of current MRI analysis tools were designed for use in adults, a primary objective of the Developing Human Connectome Project (dHCP) is to develop optimised methodological pipelines for the analysis of neonatal structural, resting state, and diffusion MRI data. Here, in an independent neonatal dataset we have extended and optimised the dHCP fMRI preprocessing pipeline for the analysis of stimulus-response fMRI data. We describe and validate this extended dHCP fMRI preprocessing pipeline to analyse changes in brain activity evoked following an acute noxious stimulus applied to the infant's foot. We compare the results obtained from this extended dHCP pipeline to results obtained from a typical FSL FEAT-based analysis pipeline, evaluating the pipelines' outputs using a wide range of tests. We demonstrate that a substantial increase in spatial specificity and sensitivity to signal can be attained with a bespoke neonatal preprocessing pipeline through optimised motion and distortion correction, ICA-based denoising, and haemodynamic modelling. The improved sensitivity and specificity, made possible with this extended dHCP pipeline, will be paramount in making further progress in our understanding of the development of sensory processing in the infant brain.

Highlights • The dHCP fMRI preprocessing pipeline is generalizable to stimulus-evoked datasets. • Customised FIX denoising in infant fMRI data substantially improves data quality. • The dHCP pipeline greatly improves spatial specificity and sensitivity to signal. • Bespoke fMRI data analysis outperforms typical analytical methods for neonatal data.

== Original document ==

The different versions of the original document can be found in:

* [http://europepmc.org/articles/PMC6347570 http://europepmc.org/articles/PMC6347570]

* [http://ora.ox.ac.uk/objects/uuid: http://ora.ox.ac.uk/objects/uuid:]

* [https://doi.org/10.1016/j.neuroimage.2018.11.006 https://doi.org/10.1016/j.neuroimage.2018.11.006] under the license cc-by

* [https://dx.doi.org/10.1016/j.neuroimage.2018.11.006 https://dx.doi.org/10.1016/j.neuroimage.2018.11.006]

* [https://api.elsevier.com/content/article/PII:S1053811918320767?httpAccept=text/xml https://api.elsevier.com/content/article/PII:S1053811918320767?httpAccept=text/xml],
: [https://api.elsevier.com/content/article/PII:S1053811918320767?httpAccept=text/plain https://api.elsevier.com/content/article/PII:S1053811918320767?httpAccept=text/plain],
: [http://dx.doi.org/10.1016/j.neuroimage.2018.11.006 http://dx.doi.org/10.1016/j.neuroimage.2018.11.006] under the license https://www.elsevier.com/tdm/userlicense/1.0/

* [https://dblp.uni-trier.de/db/journals/neuroimage/neuroimage186.html#BaxterFMGJSADS19 https://dblp.uni-trier.de/db/journals/neuroimage/neuroimage186.html#BaxterFMGJSADS19],
: [https://www.sciencedirect.com/science/article/pii/S1053811918320767 https://www.sciencedirect.com/science/article/pii/S1053811918320767],
: [https://www.paediatrics.ox.ac.uk/publications/943724 https://www.paediatrics.ox.ac.uk/publications/943724],
: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347570 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347570],
: [https://www.ndcn.ox.ac.uk/publications/943724 https://www.ndcn.ox.ac.uk/publications/943724],
: [https://neuroimaging.paediatrics.ox.ac.uk/publications/943724 https://neuroimaging.paediatrics.ox.ac.uk/publications/943724],
: [https://www.win.ox.ac.uk/publications/943724 https://www.win.ox.ac.uk/publications/943724],
: [https://www.neuroscience.ox.ac.uk/publications/943724 https://www.neuroscience.ox.ac.uk/publications/943724],
: [https://www.bdi.ox.ac.uk/publications/943724 https://www.bdi.ox.ac.uk/publications/943724],
: [https://ora.ouls.ox.ac.uk/objects/uuid:b86b65bc-3e01-4075-b4ce-873991b1a0da https://ora.ouls.ox.ac.uk/objects/uuid:b86b65bc-3e01-4075-b4ce-873991b1a0da],
: [https://academic.microsoft.com/#/detail/2899981653 https://academic.microsoft.com/#/detail/2899981653]

* [https://discovery.ucl.ac.uk/id/eprint/10063907 https://discovery.ucl.ac.uk/id/eprint/10063907],
: [https://discovery.ucl.ac.uk/id/eprint/10063907/1/1-s2.0-S1053811918320767-main.pdf https://discovery.ucl.ac.uk/id/eprint/10063907/1/1-s2.0-S1053811918320767-main.pdf]

* [ ]

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Scipediacontent: Scipediacontent moved page Draft Content 339978612 to Andersson et al 2019a

Scipediacontent: Created page with " == Abstract == The infant brain is unlike the adult brain, with considerable differences in morphological, neurodynamic, and haemodynamic features. As the majority of curren..."