m (Move page script moved page Reese et al 1970a to Reese et al 2022a) |
|
| (One intermediate revision by one other user not shown) | |
(No difference)
| |
Latest revision as of 17:06, 25 November 2022
Summary
Drug-eluting stents were developed to counteract the severe restenosis observed after bare-metal stent implantation. The risk of restenosis still prevailed due to the inhibitory effect of the drug on endothelial healing. The current work focuses on extending a multiphysics-based modeling framework to include the effect of anti-inflammatory drugs embedded in the drugeluting stents. An additional advection-reaction-diffusion equation governing the drug transport is introduced herein. Additionally, the effect of drugs, specifically rapamycin-based ones, on the proliferation of smooth muscle cells is captured. An optimal level of drug embedment is realized through the modeling framework.
Abstract
Full Paper
